Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition.

Yadav, Sudhir K; Ito, Naoko; Soin, Devika; Ito, Kouichi; Dhib-Jalbut, Suhayl

Yadav, Sudhir K; Ito, Naoko; Soin, Devika; Ito, Kouichi; Dhib-Jalbut, Suhayl.

Afiliação

Yadav SK; Department of Neurology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Ito N; Department of Neurology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Soin D; Department of Neurology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Ito K; Touro College of Osteopathic Medicine, Middletown, NY 10940, USA.
Dhib-Jalbut S; Department of Neurology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

J Clin Med ; 10(4)2021 Feb 19.

Article em En | MEDLINE | ID: mdl-33669652

Palavras-chave

Ym1+ macrophages; axonal loss; complement C3; demyelination; dimethyl fumarate; experimental autoimmune encephalomyelitis; iNOS+ macrophage; immunomodulatory; multiple sclerosis; neuroprotection; proinflammatory; reactive C3+ astrocytes

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article