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Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
Patil, Keshav; Jordan, Earl Joseph; Park, Jin H; Suresh, Krishna; Smith, Courtney M; Lemmon, Abigail A; Mossé, Yaël P; Lemmon, Mark A; Radhakrishnan, Ravi.
Afiliação
  • Patil K; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6315.
  • Jordan EJ; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073.
  • Park JH; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073.
  • Suresh K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6073.
  • Smith CM; Department of Pharmacology, Yale University, New Haven, CT 06520.
  • Lemmon AA; Cancer Biology Institute, Yale University, West Haven, CT 06516.
  • Mossé YP; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.
  • Lemmon MA; Department of Pharmacology, Yale University, New Haven, CT 06520.
  • Radhakrishnan R; Cancer Biology Institute, Yale University, West Haven, CT 06516.
Proc Natl Acad Sci U S A ; 118(10)2021 03 09.
Article em En | MEDLINE | ID: mdl-33674381
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Aprendizado de Máquina / Quinase do Linfoma Anaplásico / Mutação Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Aprendizado de Máquina / Quinase do Linfoma Anaplásico / Mutação Idioma: En Ano de publicação: 2021 Tipo de documento: Article