Direct Tissue PCR and Genotyping for Species Identification in a Case of Laryngeal Blastomycosis.
Ear Nose Throat J
; 102(4): NP157-NP160, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-33683980
ABSTRACT
Otolaryngologic manifestations of infection with Blastomyces species are extremely rare and restricted geographically to recognized endemic regions. Here, we describe a case of laryngeal blastomycosis that presented as slowly progressive dysphonia. While a preliminary diagnosis was made using routine histopathology, a species identification of Blastomyces dermatitidis was made using polymerase chain reaction amplification and rapid genotyping without the need for fungal culture. All symptoms resolved following 1 month of antifungal therapy. Rapid molecular differentiation of B dermatitidis from Blastomyces gilchristii provides important insights into pathogenesis given recent recognition of differences in clinical spectra.
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Base de dados:
MEDLINE
Assunto principal:
Blastomicose
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Laringe
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article