RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.

Wendimu, Menbere Y; Alqinyah, Mohammed; Vella, Stephen; Dean, Phillip; Almutairi, Faris; Davila-Rivera, Roseanne; Rayatpisheh, Shima; Wohlschlegel, James; Moreno, Silvia; Hooks, Shelley B

Wendimu, Menbere Y; Alqinyah, Mohammed; Vella, Stephen; Dean, Phillip; Almutairi, Faris; Davila-Rivera, Roseanne; Rayatpisheh, Shima; Wohlschlegel, James; Moreno, Silvia; Hooks, Shelley B.

Afiliação

Wendimu MY; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America.
Alqinyah M; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America.
Vella S; Department of Cellular Biology, University of Georgia, Athens, GA 30602, United States of America.
Dean P; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America.
Almutairi F; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America.
Davila-Rivera R; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America.
Rayatpisheh S; Department of Biological Chemistry, University of California, Los Angeles 90095, United States of America.
Wohlschlegel J; Department of Biological Chemistry, University of California, Los Angeles 90095, United States of America.
Moreno S; Department of Cellular Biology, University of Georgia, Athens, GA 30602, United States of America.
Hooks SB; From the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, United States of America. Electronic address: shooks@uga.edu.

Cell Signal ; 83: 109974, 2021 07.

Article em En | MEDLINE | ID: mdl-33705894

Assuntos

Canais de Cálcio/metabolismo; Sinalização do Cálcio; Cálcio/metabolismo; Regulação da Expressão Gênica; Microglia/metabolismo; Proteínas RGS/metabolismo; Molécula 2 de Interação Estromal/metabolismo; Animais; Canais de Cálcio/genética; Inflamação/genética; Inflamação/metabolismo; Camundongos; Células RAW 264.7; Proteínas RGS/genética; Molécula 2 de Interação Estromal/genética

Palavras-chave

Cyclooxygenase (COX)-2; Microglia; Neuroinflammation; Regulator of G protein signaling (RGS)10; Store-operated calcium entry (SOCE); Stromal interaction molecule (STIM)2; Toll-like receptor (TLR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Regulação da Expressão Gênica / Cálcio / Microglia / Sinalização do Cálcio / Proteínas RGS / Molécula 2 de Interação Estromal Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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