Pyxinol bearing amino acid residues: Easily achievable and promising modulators of P-glycoprotein-mediated multidrug resistance.

Wang, Conghui; Gao, Meng; Liu, Shuqi; Zou, Zongji; Ren, Ruiyin; Zhang, Chen; Xie, Hao; Sun, Jingxian; Qi, Yupeng; Qu, Qi; Song, Zhihua; Yang, Gangqiang; Wang, Hongbo

Wang, Conghui; Gao, Meng; Liu, Shuqi; Zou, Zongji; Ren, Ruiyin; Zhang, Chen; Xie, Hao; Sun, Jingxian; Qi, Yupeng; Qu, Qi; Song, Zhihua; Yang, Gangqiang; Wang, Hongbo.

Afiliação

Wang C; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Gao M; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Liu S; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Zou Z; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Ren R; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Zhang C; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Xie H; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Sun J; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Qi Y; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Qu Q; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Song Z; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
Yang G; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. Electronic address: o
Wang H; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. Electronic address: h

Eur J Med Chem ; 216: 113317, 2021 Apr 15.

Article em En | MEDLINE | ID: mdl-33706147

Assuntos

Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Aminoácidos/química; Antineoplásicos/química; Resistencia a Medicamentos Antineoplásicos; Sapogeninas/química; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Sítios de Ligação; Domínio Catalítico; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Humanos; Simulação de Dinâmica Molecular; Paclitaxel/farmacologia; Relação Estrutura-Atividade

Palavras-chave

Amino acid derivatives; Molecular docking; Multidrug resistance reversal; P-glycoprotein; Pyxinol derivatives

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sapogeninas / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Resistencia a Medicamentos Antineoplásicos / Aminoácidos / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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