The role of gene therapy as a valuable treatment modality for multiple spinal pathologies.
Regen Med
; 16(2): 175-188, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33709797
ABSTRACT
The world of biomedical research has led to several breakthroughs in the treatment of various spinal pathologies. As we investigate chronic pathologies of the spine, we start to unravel the underlying molecular mechanisms through a careful analysis of mutated genetic sequences. Investigations have led to gene therapy being explored for its potential as a treatment modality. Despite only about 2% of current gene therapy trials being centered for spinal pathologies, spinal diseases are valuable targets in gene therapy administration. Through a comprehensive literature review, our objective is to discuss the molecular mechanisms behind gene therapy for spinal pathologies, the genetic targets, along with the outcomes, success, and possible pitfalls in gene therapy research and administration. The emerging development of robotic technologies and intelligent carriers are recognized as a promising innovative technique for increasing the efficiency of gene therapy and potentially resolving spinal pathologies.
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Base de dados:
MEDLINE
Assunto principal:
Doenças da Coluna Vertebral
/
Coluna Vertebral
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article