Your browser doesn't support javascript.
loading
Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor.
Cheon, Se Hyeop; Park, Sang Yeob; Sung, Ji-Hun; Lee, Jeong Gi; Choi, Se-Hee; Jang, Ji-Won; Kim, Hee-Cheol; Kim, Sung Tae; Jeong, Sehoon; Lee, Kooyeon; Jang, Dong-Jin.
Afiliação
  • Cheon SH; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Park SY; Samyang Biopharmaceuticals Corporation, Seongnam 13488, Republic of Korea.
  • Sung JH; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Lee JG; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Choi SH; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Jang JW; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Kim HC; Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Republic of Korea.
  • Kim ST; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
  • Jeong S; Department of Healthcare Information Technology, Inje University, Gimhae 50834, Republic of Korea.
  • Lee K; Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Jang DJ; Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
J Nanosci Nanotechnol ; 21(7): 4093-4097, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33715752
ABSTRACT
The purpose of this study is to produce nanostructured lipid carrier (NLC) that can solubilize poorly water-soluble velutin and verify an improved tyrosinase synthesis inhibition. A solubility test for velutin was conducted. Cetyl palmitate and caprylic/capric triglyceride were selected as solubilizer. The lipid matrix was produced using the ultrasound dispersion method. The morphology and size distribution of the produced NLC was analyzed through scanning electron microscopy (SEM) and dynamic light scattering (DLS), and the release and tyrosinase inhibition of velutin was evaluated through the Franz diffusion cell method and tyrosinase inhibition assay. Lipid matrix nanoparticles showed an average size of approximately 250 nm and polydispersity of 0.2, and it was confirmed that the velutin incorporated within nanoparticles sustained release at a constant rate over 36 hours. Due to extremely low aqueous solubility, the tyrosinase synthesis inhibition of velutin suspension was 0%, and the value of velutin incorporated within the NLC formulation was greatly improved 56.5% (40 µg/mL). As a result, it was verified that lipid-based NLC nanoparticles are an efficient formulation for the topical delivery of poorly water-soluble flavonoids such as velutin.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanoestruturas / Nanopartículas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanoestruturas / Nanopartículas Idioma: En Ano de publicação: 2021 Tipo de documento: Article