Reversible splenial lesions during febrile illness with or without white matter lesions.
Brain Dev
; 43(6): 698-704, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33715865
ABSTRACT
OBJECTIVE:
Reversible splenium lesions during febrile illness (RESLEF) are found in a spectrum. There are two types of corpus callosum (CC) lesions CC-only type, with limited lesions and the CC (+) type, with extensive white-matter lesions. This retrospective study aimed to describe the differences in clinical findings between CC-only and CC (+) lesions and the association between onset age and clinico-radiological features in RESLEF.METHODS:
Fifty-two episodes of CC-only or CC (+) lesions accompanied by neurological symptoms, e.g., seizures, delirious behavior (DB), and disturbance of consciousness (DC), from January 2008 to October 2019 were included. We analyzed the etiology (pathogen), clinical course, laboratory data, magnetic resonance imaging and electroencephalography findings, therapy, and prognosis.RESULTS:
The rate of DC in the CC (+) was significantly higher than that in the CC-only group (5/6 [83%] vs 7/46 [15%]; p = 0.0016). The median number of seizures in the CC (+) was also significantly higher than that in the CC-only group (4 [0-7] vs 0 [0-7]; p = 0.034). Further, in RESLEF, the median onset age (months) in the seizure was significantly lower than that in the no-seizure group (39 [12-74] vs 83 [28-174]; p = 0.0007). The median onset age (months) in the DB was significantly higher than that in the no-DB group (74.5 [26-174] vs 28 [12-139]; p = 0.003).CONCLUSIONS:
In RESLEF, CC (+) is a more severe neurological symptom than CC-only. Furthermore, the onset age is related to the type of neurological symptoms that appear.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Convulsões
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Encefalopatias
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Doenças Transmissíveis
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Transtornos da Consciência
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Corpo Caloso
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Febre
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Substância Branca
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article