A glycine substitution in the collagenous domain of Col4a3 in mice recapitulates late onset Alport syndrome.

Odiatis, Christoforos; Savva, Isavella; Pieri, Myrtani; Ioannou, Pavlos; Petrou, Petros; Papagregoriou, Gregory; Antoniadou, Kyriaki; Makrides, Neoklis; Stefanou, Charalambos; Ljubanovic, Danica Galesic; Nikolaou, Georgios; Borza, Dorin-Bogdan; Stylianou, Kostas; Gross, Oliver; Deltas, Constantinos

Odiatis, Christoforos; Savva, Isavella; Pieri, Myrtani; Ioannou, Pavlos; Petrou, Petros; Papagregoriou, Gregory; Antoniadou, Kyriaki; Makrides, Neoklis; Stefanou, Charalambos; Ljubanovic, Danica Galesic; Nikolaou, Georgios; Borza, Dorin-Bogdan; Stylianou, Kostas; Gross, Oliver; Deltas, Constantinos.

Afiliação

Odiatis C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Savva I; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Pieri M; Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Cyprus.
Ioannou P; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Petrou P; Department of Biochemistry, The Cyprus Institute of Neurology and Genetics, Cyprus.
Papagregoriou G; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Antoniadou K; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Makrides N; Department of Developmental Functional Genetics, The Cyprus Institute of Neurology and Genetics, Cyprus.
Stefanou C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.
Ljubanovic DG; Department for Nephropathology and Electron microscopy, University of Zagreb, Croatia.
Nikolaou G; Veterinary diagnostic laboratory, Vet ex Machina LTD, Nicosia, Cyprus.
Borza DB; Dept. of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, TN, United States of America.
Stylianou K; Department of Nephrology, University of Crete Medical School, Greece.
Gross O; Clinic for Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.
Deltas C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.

Matrix Biol Plus ; 9: 100053, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33718859

Palavras-chave

ARAS, autosomal recessive alport syndrome; AS, alport syndrome; Alport syndrome; BSA, bovine serum albumin; Collagen-IV; EM, electron microscopy; ESRD, end stage renal disease; GBM, glomerular basement membrane; Glomerular basement membrane; Glycine missense mutation; Kidney disease; Mouse model; PAS, periodic acid schiff; TBM, tubular basement membrane; TGF-b1, transforming growth factor beta1; UPR, unfolded protein response

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article