Trinuclear and tetranuclear iron(III) complexes with fenamates: Structure and biological profile.
J Inorg Biochem
; 218: 111410, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33721718
ABSTRACT
The interaction of FeCl3 with the fenamate non-steroidal anti-inflammatory drugs has led to the formation and isolation of trinuclear iron(III) complexes, while in the presence of the nitrogen-donors 2,2'-bipyridine or pyridine tetranuclear iron(III) complexes were derived. The five resultant complexes were characterized by diverse techniques (including infrared, electronic and Mössbauer spectroscopy) and their crystal structures were determined by single-crystal X-ray crystallography. These complexes are the first structurally characterized Fe(III)-fenamato complexes. The complexes were evaluated for their ability to scavenge in vitro free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2Î-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid). The in vitro binding affinity of the complexes to calf-thymus (CT) DNA was examined and their interaction with serum albumins was also investigated. In total, the complexes present promising activity against the radicals tested, and they may bind tightly to CT DNA possibly via intercalation and reversibly to serum albumins.
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Base de dados:
MEDLINE
Assunto principal:
DNA
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Soroalbumina Bovina
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Fenamatos
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Complexos de Coordenação
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Albumina Sérica Humana
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Ferro
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article