Silencing of CREB Inhibits HDAC2/TLR4/NF-&#954;B Cascade to Relieve Severe Acute Pancreatitis-Induced Myocardial Injury.

Pan, Longfei; Niu, Zequn; Gao, Yanxia; Wang, Liming; Liu, Zhong; Liu, Jie; Sun, Jiangli; Pei, Honghong

Silencing of CREB Inhibits HDAC2/TLR4/NF-κB Cascade to Relieve Severe Acute Pancreatitis-Induced Myocardial Injury.

Pan, Longfei; Niu, Zequn; Gao, Yanxia; Wang, Liming; Liu, Zhong; Liu, Jie; Sun, Jiangli; Pei, Honghong.

Afiliação

Pan L; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China. panlonf@yeah.net.
Niu Z; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Gao Y; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Wang L; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Liu Z; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Liu J; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Sun J; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.
Pei H; Department of Emergency, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, 710004, Xi'an, Shaanxi Province, People's Republic of China.

Inflammation ; 44(4): 1565-1580, 2021 Aug.

Article em En | MEDLINE | ID: mdl-33725236

Assuntos

Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/antagonistas & inibidores; Histona Desacetilase 2/antagonistas & inibidores; Miócitos Cardíacos/metabolismo; NF-kappa B/antagonistas & inibidores; Pancreatite/metabolismo; Receptor 4 Toll-Like/antagonistas & inibidores; Animais; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/biossíntese; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética; Inativação Gênica/fisiologia; Histona Desacetilase 2/biossíntese; Histona Desacetilase 2/genética; Masculino; Miócitos Cardíacos/patologia; NF-kappa B/biossíntese; NF-kappa B/genética; Pancreatite/genética; Pancreatite/prevenção & controle; Gravidade do Paciente; Ratos; Ratos Sprague-Dawley; Receptor 4 Toll-Like/biossíntese; Receptor 4 Toll-Like/genética

Palavras-chave

CREB; HDAC2; TLR4/NF-κB signal pathway; cardiomyocytes; myocardial injury; severe acute pancreatitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pancreatite / NF-kappa B / Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico / Miócitos Cardíacos / Receptor 4 Toll-Like / Histona Desacetilase 2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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