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Structure-Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity.
Albanese, Valentina; Ruzza, Chiara; Marzola, Erika; Bernardi, Tatiana; Fabbri, Martina; Fantinati, Anna; Trapella, Claudio; Reinscheid, Rainer K; Ferrari, Federica; Sturaro, Chiara; Calò, Girolamo; Amendola, Giorgio; Cosconati, Sandro; Pacifico, Salvatore; Guerrini, Remo; Preti, Delia.
Afiliação
  • Albanese V; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Ruzza C; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy.
  • Marzola E; LTTA Laboratory for Advanced Therapies, Technopole of Ferrara, 44121 Ferrara, Italy.
  • Bernardi T; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Fabbri M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Fantinati A; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Trapella C; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Reinscheid RK; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
  • Ferrari F; LTTA Laboratory for Advanced Therapies, Technopole of Ferrara, 44121 Ferrara, Italy.
  • Sturaro C; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany.
  • Calò G; Institute of Physiology I, University Hospital Münster, University of Münster, 48149 Münster, Germany.
  • Amendola G; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy.
  • Cosconati S; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy.
  • Pacifico S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti, 2, 35131 Padova, Italy.
  • Guerrini R; "DiSTABiF", Università della Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
  • Preti D; "DiSTABiF", Università della Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
J Med Chem ; 64(7): 4089-4108, 2021 04 08.
Article em En | MEDLINE | ID: mdl-33733768
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazóis / Pirazinas / Receptores de Neuropeptídeos / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazóis / Pirazinas / Receptores de Neuropeptídeos / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2021 Tipo de documento: Article