Systemic Associations of Sarcoid Uveitis: Correlation With Uveitis Phenotype and Ethnicity.
Am J Ophthalmol
; 229: 169-175, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-33737030
ABSTRACT
PURPOSE:
To examine systemic associations of sarcoid uveitis and association with uveitis clinical phenotype and ethnicity.DESIGN:
Retrospective cross-sectional study.SUBJECTS:
A total of 362 subjects with definite or presumed sarcoid uveitis from Moorfields Eye Hospital, Royal Victorian Eye and Ear, and Auckland District Health Board.METHODS:
Data were collected from the review of clinical notes, imaging, and investigations. Sarcoidosis was diagnosed in accordance with the International Workshop on Ocular Sarcoidosis guidelines. MAIN OUTCOMEMEASURE:
Diagnosis of associated systemic disease secondary to sarcoidosis.RESULTS:
A total of 362 subjects with sarcoid uveitis were identified. Median age was 46 years, and 226 (62.4%) were female. Granulomatous anterior uveitis (47.8%), intermediate uveitis with snowballs (46.4%), and multifocal choroiditis (43.1%) were the most frequent clinical presentations, and disease was bilateral in 313 (86.5%). Periphlebitis was observed in 21.0%, and solitary optic nerve or choroidal granuloma in 11.3%. Lung parenchymal disease was diagnosed in 200 subjects (55.2%), cutaneous sarcoid in 98 (27.1%), sarcoid arthritis in 57 (15.7%), liver involvement in 21 (5.8%), neurosarcoid in 49 (13.5%), and cardiac sarcoid in 16 subjects (4.4%). Subjects with cardiac sarcoid were less likely to have granulomatous anterior uveitis (P = .017). Caucasian subjects were older at presentation (48 vs 41 years; P = .009), had less granulomatous anterior uveitis (26.4% vs 51.7%; P < .001), and were less likely to present with cutaneous involvement (23.1% vs 35.4%; P = .040).CONCLUSIONS:
Ophthalmologists need to be aware of the systemic associations of sarcoid uveitis, in particular potentially life-threatening complications such as cardiac sarcoidosis. Differences observed in uveitis phenotype and between ethnicities require further investigation.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sarcoidose
/
Uveíte
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article