Complement component factor B has thrombin-like activity.
Biochem Biophys Res Commun
; 552: 17-22, 2021 05 07.
Article
em En
| MEDLINE
| ID: mdl-33740660
ABSTRACT
Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate immune network, coagulation and complement. Both pathways, if uncontrolled due to a variety of causes, are pathogenic in numerous diseases, including coagulation disorders and infectious diseases. Previous studies have reported sequence homologies, functional similarities and interplay between these two pathways with some implications in health and disease. The current study newly reveals that complement component factor B (Bf), the second component of the alternative complement pathway, has thrombin-like activity, which is supported by a characteristic homology of the trypsin-like domain of Bf to that of thrombin. Moreover, we newly report that the trypsin-like domain of Bf is closely related to Limulus clotting factor C, the LPS sensitive clotting factor of the innate immune system. We will also discuss potential implications of our findings in diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tripsina
/
Fator B do Complemento
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Trombina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article