Cervical cord myelin abnormality is associated with clinical disability in multiple sclerosis.
Mult Scler
; 27(14): 2191-2198, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-33749378
ABSTRACT
BACKGROUND:
Myelin water imaging (MWI) was recently optimized to provide quantitative in vivo measurement of spinal cord myelin, which is critically involved in multiple sclerosis (MS) disability.OBJECTIVE:
To assess cervical cord myelin measurements in relapsing-remitting multiple sclerosis (RRMS) and progressive multiple sclerosis (ProgMS) participants and evaluate the correlation between myelin measures and clinical disability.METHODS:
We used MWI data from 35 RRMS, 30 ProgMS, and 28 healthy control (HC) participants collected at cord level C2/C3 on a 3 T magnetic resonance imaging (MRI) scanner. Myelin heterogeneity index (MHI), a measurement of myelin variability, was calculated for whole cervical cord, global white matter, dorsal column, lateral and ventral funiculi. Correlations were assessed between MHI and Expanded Disability Status Scale (EDSS), 9-Hole Peg Test (9HPT), timed 25-foot walk, and disease duration.RESULTS:
In various regions of the cervical cord, ProgMS MHI was higher compared to HC (between 9.5% and 31%, p ⩽ 0.04) and RRMS (between 13% and 26%, p ⩽ 0.02), and ProgMS MHI was associated with EDSS (r = 0.42-0.52) and 9HPT (r = 0.45-0.52).CONCLUSION:
Myelin abnormalities within clinically eloquent areas are related to clinical disability. MWI metrics have a potential role for monitoring subclinical disease progression and adjudicating treatment efficacy for new therapies targeting ProgMS.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla Crônica Progressiva
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Esclerose Múltipla Recidivante-Remitente
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Medula Cervical
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article