Piecing the Fragments Together: Dynamical Insights into the Enhancement of BRD4-BD1 (BET Protein) Druggability in Cancer Chemotherapy Using Novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives.

Akawa, Oluwole B; Soremekun, Opeyemi S; Olotu, Fisayo A; Solima, Mahmoud E S

Akawa, Oluwole B; Soremekun, Opeyemi S; Olotu, Fisayo A; Solima, Mahmoud E S.

Afiliação

Akawa OB; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Soremekun OS; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Olotu FA; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Solima MES; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.

Curr Pharm Biotechnol ; 23(3): 444-456, 2022.

Article em En | MEDLINE | ID: mdl-33749556

Assuntos

Neoplasias; Proteínas Nucleares; Proteínas de Ciclo Celular; Descoberta de Drogas; Humanos; Fatores de Transcrição

Palavras-chave

Bromodomain-containing Protein 4 Bromodomain 1 (BRD4-BD1); Fragmentation-based drug discovery; bromodomain and extraterminal proteins (BET); chemotherapy.; molecular dynamics simulation; prostate cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article