Effect of total glucosides of paeony and Tripterygium wilfordii polyglycosides on erythrocyte methotrexate polyglutamates in rats, analysed using ultra-high-performance liquid chromatography-tandem mass spectrometry.

Wu, Shulong; Mo, Liqian; Ye, Chunxiao; Xun, Tianrong; Wang, Xiaokang; Lv, Bin; Zhan, Xia; Liu, Bin; Ding, Qing; Peng, Jun; Chen, Congyan; Yang, Xixiao

Wu, Shulong; Mo, Liqian; Ye, Chunxiao; Xun, Tianrong; Wang, Xiaokang; Lv, Bin; Zhan, Xia; Liu, Bin; Ding, Qing; Peng, Jun; Chen, Congyan; Yang, Xixiao.

Afiliação

Wu S; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Mo L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Ye C; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong,China.
Xun T; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Wang X; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Lv B; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Zhan X; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Liu B; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Ding Q; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong,China.
Peng J; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Chen C; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yang X; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.

J Pharm Pharmacol ; 73(8): 1039-1048, 2021 Jul 07.

Article em En | MEDLINE | ID: mdl-33749788

Assuntos

Eritrócitos; Glucosídeos/farmacocinética; Metotrexato/análogos & derivados; Metotrexato/farmacocinética; Paeonia/química; Ácido Poliglutâmico/análogos & derivados; Tripterygium/química; Animais; Antirreumáticos/farmacocinética; Cromatografia Líquida de Alta Pressão/métodos; Medicamentos de Ervas Chinesas/farmacocinética; Eritrócitos/efeitos dos fármacos; Eritrócitos/metabolismo; Interações Ervas-Drogas; Metotrexato/análise; Ácido Poliglutâmico/análise; Ácido Poliglutâmico/farmacocinética; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Espectrometria de Massas em Tandem/métodos

Palavras-chave

Tripterygium wilfordii polyglycosides; UPLC-MS/MS; methotrexate (MTX/MTXPG1); methotrexate polyglutamates; total glucosides of paeony (TGP)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Poliglutâmico / Metotrexato / Tripterygium / Paeonia / Eritrócitos / Glucosídeos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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