Clinicopathological characteristics and survival outcomes for patients with mucinous colorectal cancer liver metastases undergoing hepatic resection: A systematic review and meta-analysis.
Am J Surg
; 222(3): 529-535, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-33750573
ABSTRACT
BACKGROUND:
Mucinous adenocarcinoma represents a distinct histological subtype of colorectal cancer. To date there has been limited data available for patients with colorectal cancer liver metastases (CRCLM) derived from mucinous adenocarcinoma. This systematic review and meta-analysis aims to provide data on the clinicopathological and survival outcomes of this cohort.METHODS:
Databases were searched for studies comparing clinicopathological and survival outcomes between patients with mucinous CRCLM and CRCLM from adenocarcinoma not otherwise specified who underwent liver resection. A random-effects model was used for analysis.RESULTS:
Eight studies describing 9157 patients were included. Mucinous CRCLM were positively associated with colon tumors (OR 1â 64, P = 0â 01), T3/T4 tumors (OR 1â 58, P = 0â 02), node positive tumors (OR 1â 55, P = 0â 005). The review also identified a trend towards worse overall survival in patients with mucinous CRCLM.CONCLUSIONS:
Despite the distinct clinicopathological characteristics and impaired long term outcomes of mucinous CRCLM, resection should remain the gold standard where possible.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
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Neoplasias do Colo
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Adenocarcinoma Mucinoso
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Hepatectomia
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Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article