Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases.
FEBS Lett
; 595(10): 1411-1421, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33752262
ABSTRACT
Calcium (Ca2+ ) is a second messenger essential for cellular homeostasis. Inside the cell, Ca2+ is compartmentalized and exchanged among organelles in response to both external and internal stimuli. Mitochondria-associated membranes (MAMs) provide a platform for proteins and channels involved in Ca2+ transfer between the endoplasmic reticulum (ER) and mitochondria. Deregulated Ca2+ signaling and proteins regulating ER-mitochondria interactions have been linked to liver diseases and intensively investigated in recent years. In this review, we summarize the role of MAM-resident proteins in Ca2+ transfer and their association with different liver diseases.
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Base de dados:
MEDLINE
Assunto principal:
Cálcio
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Sinalização do Cálcio
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Retículo Endoplasmático
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Hepatopatias
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Mitocôndrias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article