Berberis lyceum and Fumaria indica: in vitro cytotoxicity, antioxidant activity, and in silico screening of their selected phytochemicals as novel hepatitis C virus nonstructural protein 5A inhibitors.

Brice Landry, Koloko; Tariq, Somayya; Malik, Ayesha; Sufyan, Muhammad; Ashfaq, Usman Ali; Ijaz, Bushra; Shahid, Ahmad Ali

Berberis lyceum and Fumaria indica: in vitro cytotoxicity, antioxidant activity, and in silico screening of their selected phytochemicals as novel hepatitis C virus nonstructural protein 5A inhibitors.

Brice Landry, Koloko; Tariq, Somayya; Malik, Ayesha; Sufyan, Muhammad; Ashfaq, Usman Ali; Ijaz, Bushra; Shahid, Ahmad Ali.

Afiliação

Brice Landry K; Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Tariq S; Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Malik A; Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Sufyan M; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
Ashfaq UA; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
Ijaz B; Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Shahid AA; Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

J Biomol Struct Dyn ; 40(17): 7829-7851, 2022 10.

Article em En | MEDLINE | ID: mdl-33764266

Assuntos

Berberis; Fumaria; Hepatite C; Antioxidantes/farmacologia; Antivirais/química; Berberis/metabolismo; Hepacivirus/metabolismo; Simulação de Acoplamento Molecular; Compostos Fitoquímicos/metabolismo; Compostos Fitoquímicos/farmacologia; Extratos Vegetais/metabolismo; Extratos Vegetais/farmacologia; Proteínas não Estruturais Virais/química

Palavras-chave

Berberis lyceum; Fumaria indica; HCV NS5A; antioxidant activity; cytotoxicity; in silico molecular docking; molecular dynamics simulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite C / Berberis / Fumaria Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite C / Berberis / Fumaria Idioma: En Ano de publicação: 2022 Tipo de documento: Article