Lack of Association Between TNF-alpha rs1800629 (-308G > A) Polymorphism and Nephrotic Syndrome.
Iran J Kidney Dis
; 1(2): 95-100, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33764319
ABSTRACT
INTRODUCTION:
Idiopathic Nephrotic Syndrome is a multifactorial disease that accompanying with immune system dysfunction. Cytokines as potent immunomodulators have a key role in pathogenesis of the disease. We aimed to evaluate the association between TNFα -308G > A polymorphism with Idiopathic Nephrotic Syndrome and its effect on the response to steroid therapy.METHODS:
This case-control study was performed on 168 patients with Nephrotic Syndrome and 153 healthy children. Genotyping of TNF-α rs1800629 (-308G > A) variant was detected by polymerase chain reaction restriction fragment length polymorphism method (PCR-RFLP).RESULTS:
The results revealed that there was no significant difference in allele (P > .05, OR = 0.92, 95% CI 0.59 to 1.43) or genotype (P > .05, OR = 1.00; 95% CI 0.62 to 1.65) frequency of TNF-α rs1800629 (-308G > A) between childhood cases of nephrotic syndrome and healthy controls. Also no association was found between genotype (P > .05, OR = 2.28; 95% CI 1.03 to 5.04), and allele frequency (P > .05, OR = 1.93; 95% CI 0.97 to 3.87) among the SSNS and SRNS groups.CONCLUSION:
Our results did not support any association between the TNF polymorphism and the risk of nephrotic syndrome in a sample of southeast Iranian population.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Síndrome Nefrótica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article