Decoding signaling pathways involved in prolactin-induced neuroprotection: A review.
Front Neuroendocrinol
; 61: 100913, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33766566
ABSTRACT
It has been well recognized that prolactin (PRL), a pleiotropic hormone, has many functions in the brain, such as maternal behavior, neurogenesis, and neuronal plasticity, among others. Recently, it has been reported to have a significant role in neuroprotection against excitotoxicity. Glutamate excitotoxicity is a common alteration in many neurological and neurodegenerative diseases, leading to neuronal death. In this sense, several efforts have been made to decrease the progression of these pathologies. Despite various reports of PRL's neuroprotective effect against excitotoxicity, the signaling pathways that underlie this mechanism remain unclear. This review aims to describe the most recent and relevant studies on the molecular signaling pathways, particularly, PI3K/AKT, NF-κB, and JAK2/STAT5, which are currently under investigation and might be implicated in the molecular mechanisms that explain the PRL effects against excitotoxicity and neuroprotection. Remarkable neuroprotective effects of PRL might be useful in the treatment of some neurological diseases.
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Base de dados:
MEDLINE
Assunto principal:
Fármacos Neuroprotetores
/
Neuroproteção
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article