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Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop.
Bai, Lu; Vienne, Margaux; Tang, Ling; Kerdiles, Yann; Etiennot, Marion; Escalière, Bertrand; Galluso, Justine; Wei, Haiming; Sun, Rui; Vivier, Eric; Peng, Hui; Tian, Zhigang.
Afiliação
  • Bai L; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Vienne M; Institute of Immunology, University of Science and Technology of China, Hefei, China.
  • Tang L; Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.
  • Kerdiles Y; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Etiennot M; Institute of Immunology, University of Science and Technology of China, Hefei, China.
  • Escalière B; Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.
  • Galluso J; Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.
  • Wei H; Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.
  • Sun R; Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.
  • Vivier E; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Peng H; Institute of Immunology, University of Science and Technology of China, Hefei, China.
  • Tian Z; Research Unit for NK Cell Study, Chinese Academy of Medical Sciences, Beijing, China.
Science ; 371(6536)2021 03 26.
Article em En | MEDLINE | ID: mdl-33766856
ABSTRACT
The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin-Sca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes Lin-CD122+CD49a+ progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR+ liver progenitors. Thus, an IFN-γ-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos / Interferon gama / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos / Interferon gama / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article