The Yin and Yang of Histone Marks in Transcription.
Annu Rev Genomics Hum Genet
; 22: 147-170, 2021 08 31.
Article
em En
| MEDLINE
| ID: mdl-33781079
ABSTRACT
Nucleosomes wrap DNA and impede access for the machinery of transcription. The core histones that constitute nucleosomes are subject to a diversity of posttranslational modifications, or marks, that impact the transcription of genes. Their functions have sometimes been difficult to infer because the enzymes that write and read them are complex, multifunctional proteins. Here, we examine the evidence for the functions of marks and argue that the major marks perform a fairly small number of roles in either promoting transcription or preventing it. Acetylations and phosphorylations on the histone core disrupt histone-DNA contacts and/or destabilize nucleosomes to promote transcription. Ubiquitylations stimulate methylations that provide a scaffold for either the formation of silencing complexes or resistance to those complexes, and carry a memory of the transcriptional state. Tail phosphorylations deconstruct silencing complexes in particular contexts. We speculate that these fairly simple roles form the basis of transcriptional regulation by histone marks.
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Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Código das Histonas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article