Juvenile myoclonic epilepsy: Long-term prognosis and risk factors.
Brain Dev
; 43(6): 688-697, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33781581
ABSTRACT
OBJECTIVE:
Our goal was to investigate the long-term clinical course of juvenile myoclonic epilepsy (JME) in a cohort of patients and to identify prognostic factors for refractoriness and seizure relapse after anti-seizure medications (ASMs) withdrawal. A literature review is also presented to consolidate and compare our findings with the previously reported cases.METHODS:
We retrospectively studied a series of patients diagnosed with JME with 15 years or more of evolution. We collected clinical, neurophysiological and neuroimaging data from patients who met defined inclusion and exclusion criteria.RESULTS:
Study involved 61 patients (65.5% female) with mean age at study of 37.6 years, and mean age at its outset of 14.8 years. Median follow-up was 31.0 years (mean 28.9, range 15-53). They presented more frequently with a combination of myoclonic and generalized tonic-clonic seizures (GTCS) (65.6%). Sixty-five percent of patients (n = 40) had a 5-year terminal remission with a mean age at last seizure of 27.4 years. Thirty-two percent of seizure-free patients (n = 13) withdrew ASMs 6 out of 13 had a recurrence of the seizures while 7 remained seizure-free (mean age at ASMs withdrawal 21.0 versus 35.7 years, p < 0.05). In the multivariate model, a high GTCS frequency at onset (p = 0.026) was a prognostic factor of drug resistance.CONCLUSION:
JME is often regarded as a benign epileptic syndrome, although a quarter of the individuals have refractory epilepsy. The possibility of withdrawing ASMs in patients who have been free of seizures over an extended time seems feasible.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Avaliação de Resultados em Cuidados de Saúde
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Epilepsia Mioclônica Juvenil
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Epilepsia Resistente a Medicamentos
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Anticonvulsivantes
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article