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Brain MRI findings in newborns with congenital cytomegalovirus infection: results from a large cohort study.
Vande Walle, Caroline; Keymeulen, Annelies; Schiettecatte, Eva; Acke, Frederic; Dhooge, Ingeborg; Smets, Koenraad; Herregods, Nele.
Afiliação
  • Vande Walle C; Department of Radiology and Nuclear Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium. vandewalle.caroline@gmail.com.
  • Keymeulen A; Department of Neonatology, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
  • Schiettecatte E; Department of Radiology and Nuclear Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
  • Acke F; Department of Otorhinolaryngology, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
  • Dhooge I; Department of Otorhinolaryngology, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
  • Smets K; Department of Neonatology, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
  • Herregods N; Department of Radiology and Nuclear Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Gent, Belgium.
Eur Radiol ; 31(10): 8001-8010, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33787973
ABSTRACT

OBJECTIVE:

To investigate the spectrum and frequency of abnormalities on brain MRI in a large cohort of live newborns with congenital CMV (cCMV) infection.

METHODS:

Institutional review board approval and informed consent for neonatal MRI and data collection were obtained. Between January 2010 and January 2018, brain MRI was performed in 196 live newborns diagnosed with cCMV. Images were independently reviewed by 2 pediatric radiologists, blinded to clinical data.

RESULTS:

cCMV infection was clinically symptomatic in 26/191 newborns (13.6%). Brain MRI showed abnormalities in 76/196 patients (38.8%). MRI was abnormal in 20/26 clinically symptomatic patients (76.9%) 76.9% showed white matter lesions, 61.5% subependymal cysts, 46.2% ventriculomegaly, 26.9% ventricular adhesions, 26.9% gyral abnormalities, 24.0% calcifications, 15.4% cerebellar anomalies. MRI was abnormal in 55/165 (33.3%) clinically asymptomatic patients 30.9% had white matter lesions, 15.8% subependymal cysts, 4.2% ventriculomegaly, 2.4% ventricular adhesions, 1.2% gyral abnormalities, 0.6% calcifications, none had cerebellar anomalies. Concomitant brain lesions were seen in all patients with gyral abnormalities, cerebellar anomalies, and calcifications and nearly all patients with subependymal cysts and ventriculomegaly. In all but 4 patients with other detected brain lesions, white matter abnormalities were simultaneously present. In 33/74 patients (45.2%), white matter lesions were seen as a sole abnormality.

CONCLUSION:

White matter lesions were the most common detected abnormality on brain MRI in newborns with congenital CMV. Since brain abnormalities were seen in more than 30% of clinically asymptomatic and 75% of clinically symptomatic newborns, MRI should be advised in all newborns diagnosed with cCMV. KEY POINTS • Neonatal brain MRI showed abnormalities in more than 30% of clinically asymptomatic and 75% of symptomatic newborns with congenital cytomegalovirus infection. • White matter lesions were by far the most common detected abnormality, followed by subependymal cysts and ventricular dilatation. • Lesions in cCMV were often multiple, with many patients showing concomitant lesions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Citomegalovirus Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Citomegalovirus Idioma: En Ano de publicação: 2021 Tipo de documento: Article