Relationship of dehydroepiandrosterone sulfate levels with atherosclerosis in patients with subclinical hypothyroidism.
Wien Klin Wochenschr
; 134(1-2): 45-50, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-33788012
ABSTRACT
BACKGROUND:
Subclinical hypothyroidism is related with increased risk of cardiovascular diseases. The decreased levels of dehydroepiandrosterone sulphate (DHEA-S) are associated with hyperlipidemia, atherosclerosis and obesity. The lower levels of DHEAS might be an important factor in development of atherosclerosis in subclinical hypothyroidism.METHODS:
A total of 126 patients (62 with subclinical hypothyroidism and 64 healthy individuals) were included in this prospectively designed study between January 2017 and December 2019. All individuals were evaluated according to DHEAS levels, carotid intima media thickness (CIMT) and anthropometric measurements. Blood samples were obtained from patients after 8â¯h fasting. The groups were statistically compared.RESULTS:
The mean ages of control group and patients with subclinical hypothyroidism were 36.9⯱ 11.0 years and 39.6⯱ 11.0 years, respectively (pâ¯= 0.165). The mean waist circumferences in controls and patients were 89⯱ 10.7â¯cm and 91.3⯱ 11.1â¯cm, respectively (pâ¯<â¯0.001). The DHEAS levels were 131.04⯱ 96.02⯵g/dl in patients, and these levels were significantly decreased in patients with subclinical hypothyroidism (pâ¯= 0.024). The levels of DHEAS were found to be negatively correlated with CIMT (pâ¯<â¯0.001, câ¯= 0.406).CONCLUSIONS:
The early detection of cardiac and metabolic dysfunctions in subclinical hypothyroidism is important to avoid complications. We found a negative correlation between DHEAS levels and metabolic and cardiovascular risk factors in subclinical hypothyroidism. We believe that our results would attract more attention to the studies investigating relationships between DHEAS levels and cardiovascular complications of subclinical hypothyroidism.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Aterosclerose
/
Hipotireoidismo
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article