Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly.
Front Endocrinol (Lausanne)
; 12: 646210, 2021.
Article
em En
| MEDLINE
| ID: mdl-33790868
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. Pituitary tumors, although typically benign, can be locally invasive. Different studies have shown the association of EMT with increased tumor size and invasion in pituitary tumors, and in particular with a poor response to Somatostatin Receptor Ligands (SRLs) treatment in GH-producing pituitary tumors, the main cause of acromegaly. This review will summarize the current knowledge regarding EMT and SRLs resistance in acromegaly and, based on this relation, will suggest new biomarkers and possible therapies to SRLs resistant tumors.
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Base de dados:
MEDLINE
Assunto principal:
Acromegalia
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Resistência a Medicamentos
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Neoplasias das Glândulas Endócrinas
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Receptores de Somatostatina
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Adenoma Hipofisário Secretor de Hormônio do Crescimento
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Transição Epitelial-Mesenquimal
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Ligantes
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article