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Design and synthesis of C-aryl angular luotonins via a one-pot aza-Nazarov-Friedlander sequence and their Topo-I inhibition studies along with C-aryl vasicinones and luotonins.
Rasapalli, Sivappa; Sammeta, Vamshikrishna Reddy; Murphy, Zachary F; Golen, James A; Agama, Keli; Pommier, Yves; Savinov, Sergey N.
Afiliação
  • Rasapalli S; University of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, 285 Old Westport Rd, North Dartmouth, MA 02747, USA. Electronic address: srasapalli@umassd.edu.
  • Sammeta VR; University of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, 285 Old Westport Rd, North Dartmouth, MA 02747, USA.
  • Murphy ZF; University of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, 285 Old Westport Rd, North Dartmouth, MA 02747, USA.
  • Golen JA; University of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, 285 Old Westport Rd, North Dartmouth, MA 02747, USA.
  • Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255, USA.
  • Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255, USA.
  • Savinov SN; Department of Biochemistry and Molecular Biology, UMass Amherst, Amherst, MA 01003, USA.
Bioorg Med Chem Lett ; 41: 127998, 2021 06 01.
Article em En | MEDLINE | ID: mdl-33794318
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Quinonas / Desenho de Fármacos / DNA Topoisomerases Tipo I / Alcaloides / Inibidores da Topoisomerase I Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Quinonas / Desenho de Fármacos / DNA Topoisomerases Tipo I / Alcaloides / Inibidores da Topoisomerase I Idioma: En Ano de publicação: 2021 Tipo de documento: Article