Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.
Nat Commun
; 12(1): 2016, 2021 04 01.
Article
em En
| MEDLINE
| ID: mdl-33795671
ABSTRACT
We report the identification of three structurally diverse compounds - compound 4, GC376, and MAC-5576 - as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for designing SARS-CoV-2 3CL protease inhibitors. These compounds may therefore serve as leads for the basis of building effective SARS-CoV-2 3CL protease inhibitors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
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Proteases 3C de Coronavírus
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SARS-CoV-2
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Tratamento Farmacológico da COVID-19
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article