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Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Elliott, Maxwell L; Caspi, Avshalom; Houts, Renate M; Ambler, Antony; Broadbent, Jonathan M; Hancox, Robert J; Harrington, HonaLee; Hogan, Sean; Keenan, Ross; Knodt, Annchen; Leung, Joan H; Melzer, Tracy R; Purdy, Suzanne C; Ramrakha, Sandhya; Richmond-Rakerd, Leah S; Righarts, Antoinette; Sugden, Karen; Thomson, W Murray; Thorne, Peter R; Williams, Benjamin S; Wilson, Graham; Hariri, Ahmad R; Poulton, Richie; Moffitt, Terrie E.
Afiliação
  • Elliott ML; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  • Caspi A; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  • Houts RM; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
  • Ambler A; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  • Broadbent JM; King's College London, Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, & Neuroscience, London, UK.
  • Hancox RJ; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
  • Harrington H; University of Otago Faculty of Dentistry, Dunedin, New Zealand.
  • Hogan S; Department of Preventive and Social Medicine, Otago Medical School, University of Otago, New Zealand.
  • Keenan R; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  • Knodt A; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
  • Leung JH; Brain Research New Zealand-Rangahau Roro Aotearoa, Centre of Research Excellence, Universities of Auckland and Otago, New Zealand.
  • Melzer TR; Christchurch Radiology group, Christchurch, New Zealand.
  • Purdy SC; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  • Ramrakha S; School of Psychology, University of Auckland, New Zealand.
  • Richmond-Rakerd LS; Eisdell Moore Centre, University of Auckland, New Zealand.
  • Righarts A; Brain Research New Zealand-Rangahau Roro Aotearoa, Centre of Research Excellence, Universities of Auckland and Otago, New Zealand.
  • Sugden K; Department of Medicine, University of Otago, Christchurch, New Zealand.
  • Thomson WM; Brain Research New Zealand-Rangahau Roro Aotearoa, Centre of Research Excellence, Universities of Auckland and Otago, New Zealand.
  • Thorne PR; School of Psychology, University of Auckland, New Zealand.
  • Williams BS; Eisdell Moore Centre, University of Auckland, New Zealand.
  • Wilson G; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
  • Hariri AR; Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
  • Poulton R; Department of Preventive and Social Medicine, Otago Medical School, University of Otago, New Zealand.
  • Moffitt TE; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Nat Aging ; 1(3): 295-308, 2021 03.
Article em En | MEDLINE | ID: mdl-33796868
ABSTRACT
Some humans age faster than others. Variation in biological aging can be measured in midlife, but the implications of this variation are poorly understood. We tested associations between midlife biological aging and indicators of future frailty-risk in the Dunedin cohort of 1037 infants born the same year and followed to age 45. Participants' Pace of Aging was quantified by tracking declining function in 19 biomarkers indexing the cardiovascular, metabolic, renal, immune, dental, and pulmonary systems across ages 26, 32, 38, and 45 years. At age 45 in 2019, participants with faster Pace of Aging had more cognitive difficulties, signs of advanced brain aging, diminished sensory-motor functions, older appearance, and more pessimistic perceptions of aging. People who are aging more rapidly than same-age peers in midlife may prematurely need supports to sustain independence that are usually reserved for older adults. Chronological age does not adequately identify need for such supports.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragilidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragilidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article