Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections.
J Clin Med
; 10(5)2021 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-33800334
ABSTRACT
BACKGROUND:
Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate.METHODS:
We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI.RESULTS:
Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR 1.7; 95% CI 1.1-2.7, p = 0.03).CONCLUSION:
Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article