Structural and functional brain alterations revealed by neuroimaging in CNV carriers.
Curr Opin Genet Dev
; 68: 88-98, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33812299
ABSTRACT
Copy Number Variants (CNVs) are associated with elevated rates of neuropsychiatric disorders. A 'genetics-first' approach, involving the CNV effects on the brain, irrespective of clinical symptomatology, allows investigation of mechanisms underlying neuropsychiatric disorders in the general population. Recent years have seen an increasing number of larger multisite neuroimaging studies investigating the effect of CNVs on structural and functional brain endophenotypes. Alterations overlap with those found in idiopathic psychiatric conditions but effect sizes are twofold to fivefold larger. Here we review new CNV-associated structural and functional brain alterations and outline the future of neuroimaging genomics research, with particular emphasis on developing new resources for the study of high-risk CNVs and rare genomic variants.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Predisposição Genética para Doença
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Variações do Número de Cópias de DNA
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Neuroimagem
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Transtornos Mentais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article