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Structural determination of four manufacturing impurities of D&C Red No. 33.
Mazzola, Eugene P; Weisz, Adrian; Ridge, Douglas P; Donnelly, Sarah E; Zhang, Hanwen; Gonzalez, Raquel M; Ackerman, Luke K; Reese, Kristen L; Ridge, Clark D.
Afiliação
  • Mazzola EP; FDA Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland, USA.
  • Weisz A; Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
  • Ridge DP; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.
  • Donnelly SE; Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
  • Zhang H; FDA Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland, USA.
  • Gonzalez RM; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA.
  • Ackerman LK; Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
  • Reese KL; Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
  • Ridge CD; Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
Magn Reson Chem ; 59(11): 1107-1115, 2021 11.
Article em En | MEDLINE | ID: mdl-33818821
ABSTRACT
Four manufacturing impurities of D&C Red No. 33 isolated by counter-current chromatography were analyzed by NMR and ESI mass spectrometry. Three of these impurities were reported previously with minimal details of structural determination. All four are structurally related to the main component of the dye. The fourth exhibited an unusual discrepancy between the NMR structure and its chemical formula suggested by ESI-MS results. Structural determination and assignment of the main component and four impurities are discussed as well as resolution of the discrepancy between the NMR and ESI-MS results of the fourth impurity.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article