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Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities.
Shawky, Ahmed M; Abdalla, Ashraf N; Ibrahim, Nashwa A; Abourehab, Mohammed A S; Gouda, Ahmed M.
Afiliação
  • Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Central Laboratory for Micro-analysis, Minia University, Minia, 61519, Egypt.
  • Abdalla AN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Departmentof Pharmacology and Toxicology, Medicinal and Aromatic Plants Research Institute, National Center for Research, Khartoum, 2404, Sudan.
  • Ibrahim NA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
  • Abourehab MAS; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
  • Gouda AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address: ahmed.gouda@pharm.bsu.edu.eg.
Eur J Med Chem ; 218: 113403, 2021 Jun 05.
Article em En | MEDLINE | ID: mdl-33823396
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Resistência a Múltiplos Medicamentos / Subfamília B de Transportador de Cassetes de Ligação de ATP / Descoberta de Drogas / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Resistência a Múltiplos Medicamentos / Subfamília B de Transportador de Cassetes de Ligação de ATP / Descoberta de Drogas / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article