Association between early enteral nutrition and clinical outcome in patients with severe acute heart failure who require invasive mechanical ventilation.
JPEN J Parenter Enteral Nutr
; 46(2): 443-453, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-33826177
ABSTRACT
BACKGROUND:
This study aimed to examine the association between early enteral nutrition (EEN) and clinical outcome in patients with severe acute heart failure (AHF).METHODS:
This retrospective observational study enrolled consecutive patients with AHF who required continuous invasive mechanical ventilation (IMV) for >48 h and were admitted to a single-center cardiac care unit (CCU). The primary outcome was CCU length of stay (LoS). We compared patients who were initiated on EN within 48 h of intubation (EEN group) with those who were initiated on EN after 49 h of intubation (delayed EN [DEN] group). Multivariate logistic regression analysis was performed to determine independent factors for primary and secondary outcomes. CCU LoS and IMV time were categorized using the median.RESULTS:
We included 86 patients with AHF (EEN group, n = 56; DEN group, n = 30) who met the inclusion criteria. The median CCU LoS was significantly shorter in the EEN group (10 [8-15] days) than in the DEN group (15 [12-26] days, P = .007). Multivariate analysis indicated that time to EN initiation was an independent factor for CCU LoS (odds ratio [OR], 8.39; 95% confidence interval [CI], 2.18-32.20; P = .002), IMV time (OR, 4.84; 95% CI, 1.37-17.20; P = .015), and incidence of infection (OR, 2.73; 95ï¼ CI, 1.04-7.18; P = .042).CONCLUSION:
EEN (within 48 h of intubation) for patients with severe AHF who require continuous IMV might be associated with reduced CCU LoS, IMV time, and incidence of infection.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Nutrição Enteral
/
Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article