Masking by hypokalemia-primary aldosteronism with undetectable aldosterone.
Clin Kidney J
; 14(4): 1269-1271, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33841871
ABSTRACT
Primary aldosteronism is the most common cause of secondary hypertension; however, the dynamic regulation of aldosterone by potassium is less well studied and current diagnostic recommendations are imprecise. We describe a young man who presented with resistant hypertension and severe hypokalemia. The workup initially revealed undetectable aldosterone despite acute potassium repletion. Chronic potassium supplementation eventually uncovered hyperaldosteronism. In situ genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was clinically responsive to changes in extracellular potassium. We highlight a unique presentation of Conn's syndrome and discuss the implications for the molecular mechanisms of potassium regulation of aldosterone.
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MEDLINE
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En
Ano de publicação:
2021
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Article