Semisynthesis of CRV431.
Org Lett
; 23(9): 3421-3425, 2021 05 07.
Article
em En
| MEDLINE
| ID: mdl-33844557
ABSTRACT
The non-immune-suppressive cyclophilin inhibitor CRV431 is a clinical candidate to cure nonalcoholic steatohepatitis (NASH) and has the potential to treat liver fibrosis and cancer incidence. Herein we report a concise chemical semisynthesis of CRV431 in four steps from the commercially available cyclosporine, featuring in this the flow-chemistry-based methylenation an intermolecular ring-closing metathesis and a Rh-catalyzed diastereoselective hydrogenation.
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MEDLINE
Idioma:
En
Ano de publicação:
2021
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Article