The role of host cell Rab GTPases in influenza A virus infections.
Future Microbiol
; 16: 445-452, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33847136
ABSTRACT
Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Evidence has shown that Rab proteins participate in the lifecycle of IAV. In this mini-review, we outline the regulatory mechanisms of different Rab proteins in the lifecycle of IAV. Understanding the role of Rab proteins in IAV infections is important to develop broad-spectrum host-targeted antiviral strategies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Proteínas rab de Ligação ao GTP
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Influenza Humana
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article