Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Neuron
; 109(10): 1675-1691.e9, 2021 05 19.
Article
em En
| MEDLINE
| ID: mdl-33848474
ABSTRACT
Tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate, in cell culture and mouse brains, that cytosolic and nuclear tau aggregates contain RNA with enrichment for small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs). Nuclear tau aggregates colocalize with and alter the composition, dynamics, and organization of nuclear speckles, membraneless organelles involved in pre-mRNA splicing. Moreover, several nuclear speckle components, including SRRM2, mislocalize to cytosolic tau aggregates in cells, mouse brains, and brains of individuals with AD, frontotemporal dementia (FTD), and corticobasal degeneration (CBD). Consistent with these alterations, we observe that the presence of tau aggregates is sufficient to alter pre-mRNA splicing. This work identifies tau alteration of nuclear speckles as a feature of tau aggregation that may contribute to the pathology of tau aggregates.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
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Proteínas tau
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RNA Nucleolar Pequeno
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article