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Lowered sensitivity of bitter taste receptors to ß-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?
Itoigawa, Akihiro; Fierro, Fabrizio; Chaney, Morgan E; Lauterbur, M Elise; Hayakawa, Takashi; Tosi, Anthony J; Niv, Masha Y; Imai, Hiroo.
Afiliação
  • Itoigawa A; Molecular Biology Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, 41-2 Kanrin, Inuyama, Aichi 484-8506, Japan.
  • Fierro F; Japan Society for the Promotion of Science, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
  • Chaney ME; The Institute of Biochemistry, Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, 76100 Rehovot, Israel.
  • Lauterbur ME; Department of Anthropology, Kent State University, Kent, OH 44242, USA.
  • Hayakawa T; Department of Ecology and Evolutionary Biology, The University of Arizona, Tucson, AZ 85721, USA.
  • Tosi AJ; Faculty of Environmental Earth Science, Hokkaido University, N10W5, Kita-ku, Sapporo, Hokkaido 060-0810, Japan.
  • Niv MY; Japan Monkey Centre, 26 Inuyamakanrin, Inuyama, Aichi 484-0081, Japan.
  • Imai H; Department of Anthropology, Kent State University, Kent, OH 44242, USA.
Proc Biol Sci ; 288(1948): 20210346, 2021 04 14.
Article em En | MEDLINE | ID: mdl-33849315
Bitter taste facilitates the detection of potentially harmful substances and is perceived via bitter taste receptors (TAS2Rs) expressed on the tongue and oral cavity in vertebrates. In primates, TAS2R16 specifically recognizes ß-glucosides, which are important in cyanogenic plants' use of cyanide as a feeding deterrent. In this study, we performed cell-based functional assays for investigating the sensitivity of TAS2R16 to ß-glucosides in three species of bamboo lemurs (Prolemur simus, Hapalemur aureus and H. griseus), which primarily consume high-cyanide bamboo. TAS2R16 receptors from bamboo lemurs had lower sensitivity to ß-glucosides, including cyanogenic glucosides, than that of the closely related ring-tailed lemur (Lemur catta). Ancestral reconstructions of TAS2R16 for the bamboo-lemur last common ancestor (LCA) and that of the Hapalemur LCA showed an intermediate sensitivity to ß-glucosides between that of the ring-tailed lemurs and bamboo lemurs. Mutagenetic analyses revealed that P. simus and H. griseus had separate species-specific substitutions that led to reduced sensitivity. These results indicate that low sensitivity to ß-glucosides at the cellular level-a potentially adaptive trait for feeding on cyanogenic bamboo-evolved independently after the Prolemur-Hapalemur split in each species.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lemur / Lemuridae Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lemur / Lemuridae Idioma: En Ano de publicação: 2021 Tipo de documento: Article