Development of an In Vivo Predictive Dissolution Methodology of Topiroxostat Immediate-Release Tablet Using In Silico Simulation.

Li, Gang; Yang, Haiyang; Liu, Wei; Shen, Chen; Ji, Yanhua; Sun, Yilu; Huo, Qing; Liu, Yang; Wang, Guopeng

Li, Gang; Yang, Haiyang; Liu, Wei; Shen, Chen; Ji, Yanhua; Sun, Yilu; Huo, Qing; Liu, Yang; Wang, Guopeng.

Afiliação

Li G; Beijing Adamadle Biotech Co., Ltd., Beijing, 100102, People's Republic of China.
Yang H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing, 100102, People's Republic of China.
Liu W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing, 100102, People's Republic of China.
Shen C; Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.
Ji Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing, 100102, People's Republic of China.
Sun Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing, 100102, People's Republic of China.
Huo Q; Department of Biomedical, Beijing Union University College of Health and Environment, Chaoyang District, Beijing, 100023, People's Republic of China. huo_q2002@aliyun.com.
Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Sunshine South Street, Fangshan District, Beijing, 100102, People's Republic of China. liuyang@bucm.edu.cn.
Wang G; Zhongcai Health (Beijing) Biological Technology Development Co., Ltd., Beijing, 101500, People's Republic of China.

AAPS PharmSciTech ; 22(3): 132, 2021 Apr 13.

Article em En | MEDLINE | ID: mdl-33851275

Assuntos

Simulação por Computador; Modelos Biológicos; Nitrilas/química; Nitrilas/farmacocinética; Piridinas/química; Piridinas/farmacocinética; Adulto; Liberação Controlada de Fármacos/fisiologia; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacocinética; Feminino; Previsões; Humanos; Modelos Lineares; Masculino; Pessoa de Meia-Idade; Comprimidos; Adulto Jovem

Palavras-chave

in vivo predictive dissolution model; mechanistic absorption model; time shifting factor; topiroxostat IR tablet

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Simulação por Computador / Modelos Biológicos / Nitrilas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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