Bioactive constituents and the molecular mechanism of Curcumae Rhizoma in the treatment of primary dysmenorrhea based on network pharmacology and molecular docking.

Tong, Huangjin; Yu, Mengting; Fei, Chenghao; Ji, De; Dong, Jiajia; Su, Lianlin; Gu, Wei; Mao, Chunqin; Li, Lin; Bian, Zhenhua; Lu, Tulin; Hao, Min; Zeng, Bailin

Tong, Huangjin; Yu, Mengting; Fei, Chenghao; Ji, De; Dong, Jiajia; Su, Lianlin; Gu, Wei; Mao, Chunqin; Li, Lin; Bian, Zhenhua; Lu, Tulin; Hao, Min; Zeng, Bailin.

Afiliação

Tong H; Department of Pharmacy, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, China; College of Pharmacy, Nanjing University of Chinese Med
Yu M; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China.
Fei C; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Ji; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Dong J; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Su L; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Gu W; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Mao C; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Li L; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Bian Z; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Wuxi TCM Hospital Affiliated with Nanjing University of Chinese Medicine, Wuxi, 214071, China.
Lu T; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: ltl209@163.com.
Hao M; College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 311402, China. Electronic address: hao_min0509@163.com.
Zeng B; Department of Pharmacy, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, China. Electronic address: bailinzeng@126.com.

Phytomedicine ; 86: 153558, 2021 Jun.

Article em En | MEDLINE | ID: mdl-33866197

Assuntos

Medicamentos de Ervas Chinesas/química; Medicamentos de Ervas Chinesas/farmacologia; Dismenorreia/tratamento farmacológico; Animais; Cálcio/metabolismo; Cromatografia Líquida de Alta Pressão; Dinoprosta/metabolismo; Modelos Animais de Doenças; Dismenorreia/metabolismo; Feminino; Humanos; Simulação de Acoplamento Molecular; Fosfatidilinositol 3-Quinases; Agregação Plaquetária/efeitos dos fármacos; Mapas de Interação de Proteínas; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Útero/efeitos dos fármacos; Útero/fisiopatologia

Palavras-chave

Active components; Molecular docking; Network pharmacology; Platelet aggregation; Primary dysmenorrhea; Rhizoma Curcumae (CR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Dismenorreia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Dismenorreia Idioma: En Ano de publicação: 2021 Tipo de documento: Article