[EBV and immunodeficiency]. / EBV et immunodépression.
Rev Med Interne
; 42(12): 832-843, 2021 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-33867195
ABSTRACT
Epstein-Barr virus (EBV), discovered in 1964, is a double-stranded DNA virus belonging to the Herpesviridae family. EBV has a lymphoid tropism with transforming capacities using different oncogenic viral proteins. This virus has two replication cycles a lytic cycle mainly occuring during primary infection and a latent cycle allowing viral persistence into host memory B cells. More than 90% of adults are seropositive for EBV worldwide, with a past history of asymptomatic or mild primary infection. EBV infection can sometimes cause life-threatening complications such as hemophagocytic lymphohistiocytosis, and lead to the development of lymphoproliferative disorders or cancers. Risk factors associated with these phenotypes have been recently described through the study of monogenic primary immune deficiencies with EBV susceptibility. We here review the virological and immunological aspects of EBV infection and EBV-related complications with an overview of current available treatments.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Vírus Epstein-Barr
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Linfo-Histiocitose Hemofagocítica
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Síndromes de Imunodeficiência
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Transtornos Linfoproliferativos
Idioma:
Fr
Ano de publicação:
2021
Tipo de documento:
Article