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Feature tracking myocardial strain analysis in patients with bileaflet mitral valve prolapse: relationship with LGE and arrhythmias.
Gatti, Marco; Palmisano, Anna; Esposito, Antonio; Fiore, Stefano; Monti, Caterina Beatrice; Andreis, Alessandro; Pistelli, Lorenzo; Vergara, Pasquale; Bergamasco, Laura; Giustetto, Carla; De Cobelli, Francesco; Fonio, Paolo; Faletti, Riccardo.
Afiliação
  • Gatti M; Radiology Unit, Department of Surgical Sciences, University of Turin, Turin, Italy.
  • Palmisano A; Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
  • Esposito A; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Fiore S; Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. esposito.antonio@hsr.it.
  • Monti CB; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. esposito.antonio@hsr.it.
  • Andreis A; Radiology Unit, Department of Surgical Sciences, University of Turin, Turin, Italy.
  • Pistelli L; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
  • Vergara P; Division of Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Bergamasco L; Division of Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Giustetto C; Arrhythmias and Cardiac Electrophysiology, Ospedale San Raffaele, Milan, Italy.
  • De Cobelli F; Department of Surgical Sciences, University of Turin, Turin, Italy.
  • Fonio P; Division of Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Faletti R; Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Eur Radiol ; 31(10): 7273-7282, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33870458
OBJECTIVES: Anatomical substrate and mechanical trigger co-act in arrhythmia's onset in patients with bileaflet mitral valve prolapse (bMVP). Feature tracking (FT) may improve risk stratification provided by cardiac magnetic resonance (CMR). The aim was to investigate differences in CMR and FT parameters in bMVP patients with and without complex arrhythmias (cVA and no-cVA). METHODS: In this retrospective study, 52 patients with bMVP underwent 1.5 T CMR and were classified either as no-cVA (n = 32; 12 males; 49.6 ± 17.4 years) or cVA (n = 20; 3 males; 44.7 ± 11.2 years), the latter group including 6 patients (1 male; 45.7 ± 12.7 years) with sustained ventricular tachycardia or ventricular fibrillation (SVT-FV). Twenty-four healthy volunteers (11 males, 36.2 ± 12.5 years) served as control. Curling, prolapse distance, mitral annulus disjunction (MAD), and late gadolinium enhancement (LGE) were recorded and CMR-FT analysis performed. Statistical analysis included non-parametric tests and binary logistic regression. RESULTS: LGE and MAD distance were associated with cVA with an odds ratio (OR) of 8.51 for LGE (95% CI 1.76, 41.28; p = 0.008) and of 1.25 for MAD (95% CI 1.02, 1.54; p = 0.03). GLS 2D (- 11.65 ± 6.58 vs - 16.55 ± 5.09 1/s; p = 0.04), PSSR longitudinal 2D (0.04 ± 1.62 1/s vs - 1.06 ± 0.35 1/s; p = 0.0001), and PSSR radial 3D (3.95 ± 1.97 1/s vs 2.64 ± 1.03 1/s; p = 0.0001) were different for SVT-VF versus the others. PDSR circumferential 2D (1.10 ± 0.54 vs. 0.84 ± 0.34 1/s; p = 0.04) and 3D (0.94 ± 0.42 vs. 0.69 ± 0.17 1/s; p = 0.04) differed between patients with and without papillary muscle LGE. CONCLUSIONS: CMR-FT allowed identifying subtle myocardial deformation abnormalities in bMVP patients at risk of SVT-VF. LGE and MAD distance were associated with cVA. KEY POINTS: • CMR-FT allows identifying several subtle myocardial deformation abnormalities in bMVP patients, especially those involving the papillary muscle. • CMR-FT allows identifying subtle myocardial deformation abnormalities in bMVP patients at risk of SVT and VF. • In patients with bMVP, the stronger predictor of cVA is LGE (OR = 8.51; 95% CI 1.76, 41.28; p = 0.008), followed by MAD distance (OR = 1.25; 95% CI 1.02, 1.54; p = 0.03).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prolapso da Valva Mitral / Gadolínio Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prolapso da Valva Mitral / Gadolínio Idioma: En Ano de publicação: 2021 Tipo de documento: Article