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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Roney, Joseph C; Li, Sunan; Farfel-Becker, Tamar; Huang, Ning; Sun, Tao; Xie, Yuxiang; Cheng, Xiu-Tang; Lin, Mei-Yao; Platt, Frances M; Sheng, Zu-Hang.
Afiliação
  • Roney JC; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U
  • Li S; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Farfel-Becker T; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Huang N; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Sun T; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Xie Y; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Cheng XT; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Lin MY; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Platt FM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
  • Sheng ZH; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA. Electronic address: shengz@ninds.nih.gov.
Dev Cell ; 56(10): 1452-1468.e8, 2021 05 17.
Article em En | MEDLINE | ID: mdl-33878344
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Estresse Fisiológico / Axônios / Doença de Niemann-Pick Tipo C / Lipídeos / Lisossomos / Distrofias Musculares Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Estresse Fisiológico / Axônios / Doença de Niemann-Pick Tipo C / Lipídeos / Lisossomos / Distrofias Musculares Idioma: En Ano de publicação: 2021 Tipo de documento: Article