Evaluation of the drug-drug interaction potential for trazpiroben (TAK-906), a D<sub>2</sub>/D<sub>3</sub> receptor antagonist for gastroparesis, towards cytochrome P450s and transporters.

Nishihara, Mitsuhiro; Ramsden, Diane; Balani, Suresh K

Evaluation of the drug-drug interaction potential for trazpiroben (TAK-906), a D₂/D₃ receptor antagonist for gastroparesis, towards cytochrome P450s and transporters.

Nishihara, Mitsuhiro; Ramsden, Diane; Balani, Suresh K.

Afiliação

Nishihara M; Drug Metabolism and Pharmacokinetics, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Ramsden D; Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co, Cambridge, MA, USA.
Balani SK; Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co, Cambridge, MA, USA.

Xenobiotica ; 51(6): 668-679, 2021 Jun.

Article em En | MEDLINE | ID: mdl-33879032

Assuntos

Gastroparesia; Transportadores de Ânions Orgânicos; Preparações Farmacêuticas; Sistema Enzimático do Citocromo P-450/metabolismo; Interações Medicamentosas; Humanos; Proteínas de Membrana Transportadoras

Palavras-chave

Trazpiroben; cytochrome P450; cytosolic reductase; drugdrug interaction; organic anion transporting polypeptide 1B1/1B3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Gastroparesia / Transportadores de Ânions Orgânicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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