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Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells.
Abdelfatah, Sara; Naß, Janine; Knorz, Caroline; Klauck, Sabine M; Küpper, Jan-Heiner; Efferth, Thomas.
Afiliação
  • Abdelfatah S; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Science, Johannes Gutenberg University, Mainz, Germany.
  • Naß J; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Science, Johannes Gutenberg University, Mainz, Germany.
  • Knorz C; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Science, Johannes Gutenberg University, Mainz, Germany.
  • Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Küpper JH; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
  • Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Science, Johannes Gutenberg University, Mainz, Germany. efferth@uni-mainz.de.
Cell Biol Toxicol ; 38(2): 325-345, 2022 04.
Article em En | MEDLINE | ID: mdl-33884520
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Pirrolizidina / Transcriptoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Pirrolizidina / Transcriptoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article