Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents.
Bioorg Chem
; 111: 104895, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33887586
ABSTRACT
A series of 4-aminoalkyl-1(2H)-phthalazinone derivatives was designed and synthesized as potential multifunctional agents for Alzheimer's disease (AD) treatment. In vitro biological assay results demonstrated that most synthesized compounds exhibited significant AChE inhibition, moderate to high MAOs inhibitory potencies and good anti-platelet aggregation abilities. Among them, compound 15b exhibited the highest inhibitory potencies towards MAO-B and MAO-A (IC50 = 0.7 µM and 6.4 µM respectively), moderate inhibition towards AChE (IC50 = 8.2 µM), and good activities against self- and Cu2+-induced Aß1-42 aggregation and platelet aggregation. Moreover, 15b also displayed antioxidant capacity, neuroprotective potency, anti-neuroinflammation and BBB permeability. These excellent results indicated that compound 15b could be worthy of further studies to be considered as a promising multifunctional candidate for the treatment of AD.
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Base de dados:
MEDLINE
Assunto principal:
Ftalazinas
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Desenho de Fármacos
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Inibidores da Colinesterase
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Fármacos Neuroprotetores
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Doença de Alzheimer
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Inibidores da Monoaminoxidase
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article