A realistic way to investigate the design, and mechanical properties of flow diverter stents.

PURPOSE: Braided flow diverters (FD) are highly sophisticated, delicate, and intricate mechanical devices used to treat intracranial aneurysms. Testing such devices in vitro, however, remains an unsolved challenge. Here, we evaluate methods to measure flow, design and mechanical properties in vitro. METHODS: Flow properties, cell porosity, pore density, and cell area were evaluated under geometrically realistic conditions by placing FDs in patient-derived, 3D-printed models of human vasculature. 4D flow MRI was used to measure fluid dynamics. Laser microscopy was used to measure the design properties of the FDs. New methods were developed to investigate the bending, circumferential, and longitudinal radial force of the FDs continuously over varying diameters. RESULTS: The placement and flow properties of the FD in the vasculature models were successfully measured by MRI, although artifacts occurred. Likewise, the porosity, pore density, and cell area were successfully measured inside of the models using a laser microscope. The newly developed mechanical methods allowed to measure the indicated forces - to our knowledge for the first time - continuously. CONCLUSION: Modern and specifically tailored techniques, some of which were presented here for the first time, allow detailed insights into the flow, design, and mechanical properties of braided flow diverter stents.